切换至 "中华医学电子期刊资源库"

中华乳腺病杂志(电子版) ›› 2012, Vol. 06 ›› Issue (01) : 91 -97. doi: 10.3877/cma. j. issn.1674-0807.2012.01.014

讲座

三阴性乳腺癌的临床特点及治疗进展
廖仕翀1, 喻莉1, 李金芯2, 孙圣荣3   
  1. 1.430014 武汉,华中科技大学同济医学院附属武汉市中心医院重症医学科
    2.430071 武汉,武汉大学医学部
    3.430061 武汉,武汉大学人民医院乳甲外科
  • 收稿日期:2010-11-10 出版日期:2012-02-01

Clinical features and treatment progress of triple negative breast cancer

Shi-chong LIAO, Li YU, Jin-xin LI, Shengrong Sun   

  • Received:2010-11-10 Published:2012-02-01
引用本文:

廖仕翀, 喻莉, 李金芯, 孙圣荣. 三阴性乳腺癌的临床特点及治疗进展[J/OL]. 中华乳腺病杂志(电子版), 2012, 06(01): 91-97.

Shi-chong LIAO, Li YU, Jin-xin LI, Shengrong Sun. Clinical features and treatment progress of triple negative breast cancer[J/OL]. Chinese Journal of Breast Disease(Electronic Edition), 2012, 06(01): 91-97.

表1 三阴性乳腺癌分子特征
图1 手术组和非手术组的生存曲线
表2 三阴性乳腺癌新型靶向治疗
[1]
Key TJ, Verkasalo PK, Banks E. Epidemiology of breast cancer[J].Lancet Oncol,2001,2(3):133-140.
[2]
Jemal A, Siegel R, Ward E, et al. Cancer statistics,2009[J]. CA Cancer J Clin,2009,59(4):225-249.
[3]
Sorlie T,Tibshirani R,Parker J,et al.Repeated observation of breast tumor subtypes in independent gene expression data sets[J].PNAS,2003,100( 14):8418-8423.
[4]
Hu Z, Fan C, Oh DS, et al.The molecular portraits of breast tumors are conserved across microarray platforms[J]. BMC Genomics,2006,7(7):96.
[5]
Turner NC, Reis-Filho JS, Russell AM, et al. BRCA1 dysfunction in sporadic basal-like breast cancer[J]. Oncogene,2007,26(14):2126-2132.
[6]
Livasy CA, Karaca G, Nanda R, et al. Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma[J].Mod Pathol,2006,19(2):264-271.
[7]
Carey LA, Perou CM, Livasy CA, et al. Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study[J].JAMA,2006,295(21):2492-2502.
[8]
韩晓蓉,郜红艺,王颀,等.三阴性乳腺癌的临床病理特点(附35 例报告) [J/CD].中华乳腺病杂志:电子版,2009,3(1):16-21.
[9]
Bauer K, Brown M, Cress R, et al. Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor(PR)-negative, and HER-2-negative invasive breast cancer, the so-called triple-negative phenotype: A population-based study from the California cancer registry[J]. Cancer,2007,109(9):1721-1728.
[10]
Morris G, Naidu S, Topham A, et al. Differences in breast carcinoma characteristics in newly diagnosed African-American and Caucasian patients: A single-institution compilation compared with the National Cancer Institute 's Surveillance, Epidemiology, and End Results database[J]. Cancer,2007,110(4):876-884.
[11]
Millikan RC, Newman B, Tse CK, et al. Epidemiology of basal-like breast cancer[J]. Breast Cancer Res Treat,2008,109(1):123-139.
[12]
Dolle JM, Daling JR, White E, et al. Risk actors for triple-negative breast cancer in women under the age of 45 years[J]. Cancer Epidemiol Biomarkers Prev,2009,18(4):1157-1166.
[13]
Lin NU, Claus E, Sohl J, et al. Sites of distant recurrence and clinical outcomes in patients with metastatic triple-negative breast cancer: high incidence of central nervous system metastases[J].Cancer,2008,113(10):2638-2645.
[14]
王姝姝.三阴性乳腺癌患者远处复发转移的位置及临床结果:高发的脑转移率[J/CD].中华乳腺病杂志:电子版,2009,3(1):113-117.
[15]
Tischkowitz M, Brunet JS, Begin LR, et al. Use of immunohistochemical markers can refine prognosis in triple negative breast cancer[J]. BMC Cancer,2007,7(24):134.
[16]
Liedtke C, Mazouni C, Hess KR, et al. Response to neoadjuvant therapy and long-term survival in patients with triplenegative breast cancer[J]. J Clin Oncol,2008,26(8):1275-1281.
[17]
Bidard FC, Matthieu MC, Chollet P, et al. p53 status and efficacy of primary anthracyclines/alkylating agent-based regimen according to breast cancer molecular classes[J]. Ann Oncol,2008,19(7):1261-1265.
[18]
Di Leo A, Isola J, Piette F, et al. A meta-analysis of phase Ⅲtrials evaluating the predictive value of HER-2 and topoisomerase Ⅱalpha in early breast cancer patients treated with CMF or anthracycline-based adjuvant therapy[J].Cancer Res,2009,69(12):705.
[19]
O'Malley FP, Chia S, Tu D, et al. Topoisomerase Ⅱalpha protein and responsiveness of breast cancer to adjuvant chemotherapy with CEF compared to CMF in the NCIC CTG randomized MA.5 adjuvant trial[J].Breast Cancer Res Treat,2011,128(2):401-409.
[20]
Jacquemier J, Penault-Llorca F, Mnif H, et al. Identification of a basal-like subtype and comparative effect of epirubicinbased chemotherapy and sequential epirubicin followed by docetaxel chemotherapy in the PACS 01 breast cancer trial: 33 markers studied on tissue-microarrays (TMA) [J]. J Clin Oncol,2006,24(3):509 .
[21]
Harris LN, Broadwater G, Lin NU, et al. Molecular subtypes of breast cancer in relation to paclitaxel response and outcomes in women with metastatic disease: results from CALGB 9342[J]. Breast Cancer Res,2006,8(6):66.
[22]
Ellis P, Barret-Lee P, Johnson L, et al. Sequential docetaxel as adjuvant chemotherapy for early breast cancer (TACT):an open-label, phase Ⅲ, randomised controlled trial[J]. Lancet,2009,373(9676):1681-1692.
[23]
Silver DP, Richardson AL,Eklund AC,et al. Efficacy of neoadjuvant cisplatin in triple-negative breast cancer[J]. J Clin Oncol,2010,28(7):1145-1153.
[24]
Sirohi B, Arnedos M, Popat S, et al. Platinum-based chemotherapy in triple-negative breast cancer[J]. Ann Oncol,2008,19(11):1847-1852.
[25]
Hoadley KA, Weigman VJ, Fan C, et al. EGFR associated expression profiles vary with breast tumor subtype[J]. BMC Genomics,2007,8(31):258.
[26]
Corkery B, Crown J, Clynes M, et al. Epidermal growth factor receptor as a potential therapeutic target in triple-negative breast cancer[J]. Ann Oncol,2009,20(5):862-867.
[27]
O'Shaughnessy J, Weckstein D, Vukelja S, et al. Preliminary results of a randomized phase Ⅱ study of weekly irinotecan/carboplatin with or without cetuximab in patients with metastatic breast cancer[J]. Breast Cancer Res Treat,2007,106(6):32.
[28]
Baselga J, Gomez P, Awada A, et al. The addition of cetuximab to cisplatin increases overall response rate (ORR) and progression-free survival (PFS) in metastatic triple-negative breast cancer (TNBC): Results of a randomized phase Ⅱstudy (BALI-1)[J]. Ann Oncol,2010,21(4):2740.
[29]
Finn RS, Lau A, Kalous O, et al. Pre-clinical activity of the PARP inhibitor AZD2281 in human breast cancer cell lines and in combination with DNA damaging agents[J]. Cancer Res,2009,69(16):1038.
[30]
O'Shaughnessy J, Osborne C, Pippen J, et al. Efficacy of BSI-201,a poly (ADP-ribose) polymerase-1 (PARP1) inhibitor,in combination with gemcitabine/carboplatin (G/C) in patients with metastatic triple-negative breast cancer (TNBC):Results of a randomized phase Ⅱtrial[J]. J Clin Oncol,2009,27(18):793.
[1] 刘伟, 牛云峰, 安杰. LINC01232 通过miR-516a-5p/BCL9 轴促进三阴性乳腺癌的恶性进展[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 330-338.
[2] 张晓宇, 殷雨来, 张银旭. 阿帕替尼联合新辅助化疗对三阴性乳腺癌的疗效及预后分析[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 346-352.
[3] 牛海刚, 郭文科. 三阴性乳腺癌组织中双特异性磷酸酶14与核受体相互作用蛋白1的表达及预后价值[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(04): 199-205.
[4] 刘世佳, 陶新楠, 史晋宇, 吕文豪, 张亚芬. 乳酸脱氢酶A在乳腺癌中的作用[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(03): 175-179.
[5] 刘琴, 刘瀚旻, 谢亮. 基质金属蛋白酶在儿童哮喘发生机制中作用的研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 564-568.
[6] 吴伟宙, 王琼仁, 詹雄宇, 郑明星, 李亚县. 广东省医学会泌尿外科疑难病例多学科会诊(第16期)——左肾肉瘤样癌[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 525-529.
[7] 李飞, 郑灶松, 吴芃, 谭万龙. 广东省医学会泌尿外科疑难病例多学科会诊(第16期)——延胡索酸水合酶缺陷型晚期肾细胞癌[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(04): 410-414.
[8] 李勇, 彭天明, 王倩倩, 陈育纯, 蒲小勇, 刘久敏. 基于失巢凋亡相关基因的膀胱癌预后模型构建及分析[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(04): 331-339.
[9] 王庭宇, 邵联波, 刘珊, 沈振亚. Stanford A 型主动脉夹层相关基因KIF20A 的共表达网络构建及作用靶点分析[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(05): 303-312.
[10] 陈伟杰, 何小东. 胆囊癌免疫靶向治疗进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 763-768.
[11] 魏妙艳, 徐近. 合并远处转移胰腺癌系统性治疗的梳理和展望[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 644-650.
[12] 李永政, 孟煜凡, 樊知遥, 展翰翔. 胰腺神经内分泌肿瘤新辅助治疗研究进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(04): 481-486.
[13] 陆思楠, 苏同荣, 张启逸. 索凡替尼转化治疗胰腺神经内分泌肿瘤肝转移一例并文献复习[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(04): 526-530.
[14] 马虹宇, 陈元武, 张明明, 岳向勇, 檀碧波. 平胃散加味联合毫火针对直肠癌患者化学治疗致胃肠道反应的疗效[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(04): 297-300.
[15] 王光伟, 李桂莲, 王勇. 散发性静脉畸形的靶向治疗进展[J/OL]. 中华介入放射学电子杂志, 2024, 12(04): 380-385.
阅读次数
全文


摘要